Novel mutations in beta-myosin heavy chain, actin and troponin-I genes associated with dilated cardiomyopathy in Indian population

摘要

Dilated cardiomyopathy (DCM) represents a large subset of congestive heart failure cases with a risk of sudden cardiac death (Kamisago et al. 2000). It is a primary myocardial disease and genetically heterogeneous disorder, characterized by progressive systolic dysfunction due to cardiac chamber dilatation and inefficient myocardial contractility.The phenotype in idiopathic/primary DCM (IDCM) is characterized by cardiac muscle dysfunction mthe absence of secondary causes and conduction defects such as atrioventricular locks / valvular dysfunction / systemic / skeletal muscular disorders in ischemic/secondary DCM.