Distinct eicosanoid profile in exhaled breath condensates from granulomatosis with polyangiitis (Wegener's) patients

摘要

Granulomatosis with polyangiitis (GPA, Wegener's) is a systemic vasculitis affecting mostly small vessels, typically involving the upper respiratory tract, lungs, and kidneys. Together with microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), and renal-limited vasculitis, it commonly shows circulating antineutrophil cytoplasmic antibodies (ANCA). As such, it is typically referred to as an ANCA-associated vasculitis [1, 2]. The pathogenesis of GPA has not been fully elucidated, although the interaction between ANCA and neutrophils seems pivotal in initiating and supporting an inflammatory reaction with subsequent cytokine, complement, and endo-thelium involvement [3].