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首页> 外文期刊>Journal of Fluid Mechanics >Modelling single- and tandem-bubble dynamics between two parallel plates for biomedical applications
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Modelling single- and tandem-bubble dynamics between two parallel plates for biomedical applications

机译:为生物医学应用建模两个平行板之间的单气泡和串联气泡动力学

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Carefully timed tandem microbubbles have been shown to produce directional and targeted membrane poration of individual cells in microfluidic systems, which could be of use in ultrasound-mediated drug and gene delivery. This study aims at contributing to the understanding of the mechanisms at play in such an interaction. The dynamics of single and tandem microbubbles between two parallel plates is studied numerically and analytically. Comparisons are then made between the numerical results and the available experimental results. Numerically, assuming a potential flow, a threedimensional boundary element method (BEM) is used to describe complex bubble deformations, jet formation, and bubble splitting. Analytically, compressibility and viscous boundary layer effects along the channel walls, neglected in the BEM model, are considered while shape of the bubble is not considered. Comparisons show that energy losses modify the bubble dynamics when the two approaches use identical initial conditions. The initial conditions in the boundary element method can be adjusted to recover the bubble period and maximum bubble volume when in an infinite medium. Using the same conditions enables the method to recover the full dynamics of single and tandem bubbles, including large deformations and fast re-entering jet formation. This method can be used as a design tool for future tandem-bubble sonoporation experiments.
机译:精心计时的串联微泡已显示可在微流体系统中产生单个细胞的定向和靶向膜渗透,可用于超声介导的药物和基因递送。这项研究旨在促进对这种相互作用中作用机理的理解。数值和分析研究了两个平行板之间的单个和串联微气泡的动力学。然后在数值结果和可用的实验结果之间进行比较。在数值上,假设有潜在的流动,则使用三维边界元方法(BEM)来描述复杂的气泡变形,射流形成和气泡分裂。从分析上看,在BEM模型中忽略了沿通道壁的可压缩性和粘性边界层效应,而未考虑气泡的形状。比较表明,当两种方法使用相同的初始条件时,能量损失会改变气泡动力学。可以调整边界元方法的初始条件,以恢复在无限大介质中的气泡周期和最大气泡体积。使用相同的条件可使该方法恢复单个气泡和串联气泡的全部动力学特性,包括大变形和快速重新形成射流。此方法可用作将来的串联气泡声穿孔实验的设计工具。

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