Take-Home Message: 1) Hyperinsulinemia, likely acting through lamellar insulin-like growth factor receptors, triggers inappropriate lamellar proliferation, lamellar weakening, and thus laminitis. Every effort should be made to identify and correct hyperinsulinemia. 2) Lamellar bioenergetics are currently being investigated in the pathophysiology of supporting limb laminitis. 3) The lamellar disintegration of carbohydrate overload-induced laminitis occurs well before clinical signs appear, as early as12 h after dosing. Targeted inhibition of the proteases which contribute to lamellar compromise is currently being studied. 4) Chronic laminitis involves dysplastic horn growth which may contribute to chronic pain, distal phalanx rotation and lysis, andpermanent structural changes to the hoof. Early hoof wall resection in the affected area may relieve compression and restore some semblance of normal hoof growth. 5) Digital hypothermia (cryotherapy) blocks the early lamellar inflammatory events likelyto play important roles in lamellar injury.
展开▼
