Participation of GABAergic Mechanisms of Hypothalamus Ventrolateral Preoptic Area in Regulation of Sleep and Wakefulness and Temperature Homeostasis in the Pigeon Columba livia

摘要

A comparative analysis of awakening,somnogenic,and thermoregulating effects of agonists and antagonists of GABA_(A,B)-receptors after microinjections to neuronal populations of ventrolateral preoptic area(VLPA)of hypothalamus was carried out for the first time in representatives of the avian class(pigeon).It has bee established that:(1)VLPA of hypothalamus contains populations of neurons differing by their function and representation of receptor types and participating in control of wakeful-ness,sleep,and thermoregulation;(2)executive GABA_A-ergic mechanisms of maintenance of the slow-wave sleep(SWS)are located predominantly in the caudal part of the hypothalamic VLPA;(3)GABA_(A,B)-ergic mechanisms of control of thermal homeostasis are located predominantly in the caudal part of VLPA.It is suggested that the maintenance of SWS depends on an increase of activity of inhibitory GABAergic VLPA mechanisms leading to inactivation of neuronal networks of wakefulness outside VLPA and on a reduction of activity of the stimulatory aminergic systems present in the preoptic area and outside it.