Association Between Serum Long-Chain n-3 and n-6 Polyunsaturated Fatty Acid Profiles and Glomerular Filtration Rate Assessed by Serum Creatinine and Cystatin C Levels in Japanese Community-Dwellers

摘要

Background: Plasma concentration of n-3 polyunsaturated fatty acids ( PUFAs) has been reported to be associated with renal function in Western populations. However, few studies have investigated the association between serum long-chain n-3 and n-6 PUFA profiles and renal function in a Japanese population with high marine-derived longchain n-3 PUFA intake. Methods: A cross-sectional study was performed in 549 Japanese rural community-dwellers aged 40 to 64 years. In adjusted analysis of covariance, we assessed the relationship between estimated glomerular filtration rate ( eGFR) and tertiles of serum long-chain n-3 and n-6 PUFA profiles ([ eicosapentaenoic acid {EPA} + docosahexaenoic acid {DHA}]: arachidonic acid [ AA]). GFR was estimated by Japanese specific equations using serum creatinine and cystatin C ( eGFR(cre) and eGFR(cys)). Using multivariate-adjusted linear regression models, we also assessed the relationships between eGFRs and several n-3 and n-6 PUFAs, which have been suggested to be associated with renal function. Results: In all participants, higher dietary fish intake as assessed by a semi-quantitative questionnaire was associated with higher serum value of ( EPA+ DHA): AA. Participants in the higher ( EPA+ DHA): AA tertiles had non-significantly higher eGFRcre and significantly higher eGFRcys ( P = 0.016). In addition, eGFRcys in T2+ T3 of ( EPA+ DHA): AA was significantly higher than that in T1 ( adjusted mean eGFRcys, T1: 87 ml/ min/ 1.73m2, T2+ T3: 91 ml/ min/ 1.73m2; P < 0.01). Among the PUFAs, only ( EPA+ DHA) was significantly associated with eGFRcys. Conclusions: Serum ( EPA+ DHA): AA, which reflects an individual's fish intake, might be associated with eGFRcys in Japanese community-dwellers.