Prevalence of gastroparesis before and after lung transplantation and its association with lung allograft outcomes

摘要

The main cause of late morbidity and mortality after lung transplantation is bronchiolitis obliterans syndrome (BOS). This study assesses the prevalence of gastroparesis among lung-transplant recipients and its association with BOS. The files of 139 patients who underwent nuclear gastric emptying studies before and/or three and 12months after lung transplantation were reviewed, and the correlation of gastric emptying time (GET) at each time point with the occurrence of acute rejection or BOS (stage 0p or higher) was evaluated. Delayed gastric emptying (DGE; t 1/290min) was documented in 50% of patients before transplantation - 74% at threemonths and 63% at 12months. Median pre-transplant t 1/2 was 108min in patients who acquired BOS and 77min in BOS-free patients (p=0.022). Among patients with pre-transplant DGE, 58% were BOS-free at 24months post-operatively and 37% at 36months; corresponding rates in patients with normal motility were 78% and 63% (p=0.084). On multiple regression analysis adjusting for other measures of upper gastrointestinal dysfunction, GET before or threemonths after transplantation was significantly associated with BOS (OR 1.05 [95% CI 1.01-1.09] and OR 1.001 [1.001-1.005] per minute t 1/2). Gastroparesis is common in lung-transplant recipients and associated with the development of BOS.