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首页> 外文期刊>Journal of diabetes and its complications >Hyperglycemia and its effect after acute myocardial infarction on cardiovascular outcomes in patients with Type 2 diabetes mellitus (HEART2D) Study design.
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Hyperglycemia and its effect after acute myocardial infarction on cardiovascular outcomes in patients with Type 2 diabetes mellitus (HEART2D) Study design.

机译:高血糖及其在急性心肌梗塞后对2型糖尿病患者的心血管结局的影响(HEART2D)研究设计。

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摘要

OBJECTIVE: Cardiovascular (CV) disease is the major cause of death in patients with diabetes. Up to 40% of patients with Type 2 diabetes mellitus (T2DM) who survive an initial myocardial infarction (MI) suffer a recurrent event within 2 years, the majority of which are fatal. One independent risk factor for cardiovascular disease (CVD) may be postprandial blood glucose (PPBG) excursions. The HEART2D study seeks to determine the effect that PPBG control has on cardiovascular outcomes in patients who suffered an MI within the 21 days before study enrollment. RESEARCH DESIGN AND METHODS: Approximately 1355 patients with T2DM with recent MI will be entered in this multicenter study of about 3.0-year duration. Using infarct severity and peri-infarct treatment as randomization factors, patients will be assigned to one of two insulin treatment strategies: (1) postprandial strategy: premeal insulin lispro with basal insulin at bedtime if needed (NPH insulin), targeting 2-h PPBG
机译:目的:心血管疾病是糖尿病患者死亡的主要原因。在最初的心肌梗死(MI)中幸存的2型糖尿病(T2DM)患者中,多达40%会在2年内复发,其中大多数是致命的。心血管疾病(CVD)的一个独立危险因素可能是餐后血糖(PPBG)漂移。 HEART2D研究旨在确定PPBG控制对入选研究前21天内患有MI的患者的心血管结局的影响。研究设计和方法:大约1355例最近MI的T2DM患者将进入这项为期约3.0年的多中心研究。使用梗塞严重程度和梗塞周围治疗作为随机因素,将为患者分配以下两种胰岛素治疗策略之一:(1)餐后策略:餐前使用赖脯胰岛素和基础胰岛素(NPH胰岛素),针对2-h PPBG

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