Synthesis and antiviral activity of novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines.

Kim HO; Kim YH; Suh H; Jeong LS

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Synthesis and antiviral activity of novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines.

机译：新型D-和L-2'-叠氮基-2'，3'-二脱氧核糖呋喃核糖基-4'-硫代嘧啶和嘌呤的合成及抗病毒活性。

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摘要

Novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines have been synthesized starting from L-xylose and D-xylose, respectively. Among synthesized compounds tested against several viruses such as HIV-1, HSV-1, HSV-2, and HCMV, D-beta-N6-methyladenine (ent-22a) and D-alpha-N6-methyladenine (ent-22b) analogues were found to exhibit significant anti-HCMV activity.

机译：分别从L-木糖和D-木糖开始合成了新的D-和L-2'-叠氮基-2'，3'-二脱氧核糖呋喃核糖基-4'-硫代嘧啶和嘌呤。在针对几种病毒（如HIV-1，HSV-1，HSV-2和HCMV）测试的合成化合物中，D-β-N6-甲基腺嘌呤（ent-22a）和D-α-N6-甲基腺嘌呤（ent-22b）类似物被发现具有显着的抗HCMV活性。

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《Bioorganic and Medicinal Chemistry Letters》 |2001年第4期|共5页
作者
Kim HO; Kim YH; Suh H; Jeong LS;
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正文语种 eng
中图分类药学;生物化学;
关键词
Antiviral Agents; Thionucleosides; 抗病毒药; 硫代核苷类;

机译：Antiviral Agents;Thionucleosides;抗病毒药;硫代核苷类;

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1. Synthesis and antiviral activity of novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines. [J] . Kim HO, Kim YH, Suh H, Bioorganic and Medicinal Chemistry Letters . 2001,第4期

机译：新型D-和L-2'-叠氮基-2'，3'-二脱氧核糖呋喃核糖基-4'-硫代嘧啶和嘌呤的合成及抗病毒活性。
2. Synthesis and Biological Evaluation of Novel D-2'-Azido-2',3'-dideoxyarabinofuranosyl-4'-thiopyrimidines and purines. [J] . Kim H, Park Y, Moon H, Bioorganic and Medicinal Chemistry Letters . 2002,第17期

机译：新型D-2'-叠氮基-2'，3'-双脱氧阿拉伯呋喃糖基-4'-硫代嘧啶和嘌呤的合成及生物学评价。
3. Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2 ',3 '-didehydro-2 ',3 '-dideoxy-2 '-fluorocarbocyclic nucleosides [J] . Wang JN, Jin YH, Rapp KL, Journal of Medicinal Chemistry . 2005,第11期

机译：D-和L-2'，3'-didehydro-2'，3'-dideoxy-2'-氟碳环核苷的合成，抗病毒活性和耐药性机制
4. Isolation and Total Synthesis and Antiviral Activity of Alkaloids from Cynanchum Komarovii and an Innovative Research for Novel Antiplant Viral Agent NK-007 [C] . Qingmin Wang Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization . 2012

机译：虎杖生物碱的分离，全合成及抗病毒活性及新型抗植物病毒制剂NK-007的创新研究
5. Synthesis of potential anti-HIV agents and prodrugs: Part I synthesis of L-3'-hydroxymethylnucleosides. Part II synthesis and pharmacokinetics of 3'-azido-2',3'-dideoxyuridine (AZDU) as prodrugs . [D] . Cooperwood, John Steven. 1999

机译：潜在的抗HIV药物和前药的合成：第I部分L-3'-羟甲基核苷的合成。第二部分3'-叠氮基2'，3'-二脱氧尿苷（AZDU）作为前药的合成和药代动力学。
6. d- and l-2′3′-Didehydro-2′3′-Dideoxy-3′-Fluoro-Carbocyclic Nucleosides: Synthesis Anti-HIV Activity and Mechanism of Resistance [O] . Jianing Wang, Yunho Jin, Kimberly L. Rapp, -1

机译：d-和l-23-Didehydro-23-Dideoxy-3-氟-碳环核苷：合成抗HIV活性和耐药机制
7. d- and l-2, 3-Didehydro-2, 3-dideoxy-3-fluoro-carbocyclic Nucleosides: Synthesis, Anti-HIV Activity, and Mechanism of Resistance [O] . -1

机译：D-和L-2，3-丁羟基-2,3-二氧化-3-氟 - 碳环核苷：合成，抗HIV活性和抗性机理
8. Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets. [R] . Walker, R. T. 1989

机译：具有抗负链RNa病毒靶标的潜在抗病毒活性的核苷类似物的合成。

Synthesis and antiviral activity of novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines.

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