首页> 外文期刊>Journal of developmental origins of health and disease >Periconceptional undernutrition suppresses cortisol response to arginine vasopressin and corticotropin-releasing hormone challenge in adult sheep offspring
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Periconceptional undernutrition suppresses cortisol response to arginine vasopressin and corticotropin-releasing hormone challenge in adult sheep offspring

机译:围孕期营养不良抑制成年绵羊后代对精氨酸升压素和促肾上腺皮质激素释放激素挑战的皮质醇反应

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摘要

Poor maternal nutrition during pregnancy can result in increased disease risk in adult offspring. Many of these effects are proposed to be mediated via altered hypothalamo-pituitary-adrenal axis (HPAA) function, and are sex and age specific. Maternal undernutrition around the time of conception alters HPAA function in foetal and early postnatal life, but there are limited conflicting data about later effects. The aim of this study was to investigate the effect of moderate periconceptional undernutrition on HPAA function of offspring of both sexes longitudinally, from juvenile to adult life. Ewes were undernourished from 61 days before until 30 days after conception or fed ad libitum. HPAA function in offspring was assessed by arginine vasopressin plus corticotropin-releasing hormone challenge at 4, 10 and 18 months. Plasma cortisol response was lower in males than in females, and was not different between singles and twins. Periconceptional undernutrition suppressed offspring plasma cortisol but not adrenocorticotropic hormone responses. In males, this suppression was apparent by 4 months, and was more profound by 10 months, with no further change by 18 months. In females, suppression was first observed at 10 months and became more profound by 18 months. Maternal undernutrition limited to the periconceptional period has a prolonged, sex-dependent effect on adrenal function in the offspring.
机译:孕期孕产妇营养不良会导致成年后代患病的风险增加。这些效应中有许多是通过改变下丘脑-垂体-肾上腺轴(HPAA)功能来介导的,并且是性别和年龄特异性的。受孕前后的母亲营养不良会改变胎儿和出生后早期生命中的HPAA功能,但有关后来发生的影响的矛盾数据有限。这项研究的目的是从幼年到成年期纵向研究中度受孕不足对两代后代HPAA功能的影响。从怀孕前的61天到怀孕后的30天,母羊的营养不足或随意喂养。在4、10和18个月时,通过精氨酸加压素加促肾上腺皮质激素释放激素的攻击评估后代的HPAA功能。男性的血浆皮质醇反应低于女性,单身和双胞胎的血浆皮质醇反应也没有差异。孕周营养不良会抑制后代血浆皮质醇,但不能抑制促肾上腺皮质激素的反应。在男性中,这种抑制作用在4个月时就很明显,在10个月时更明显,在18个月时没有进一步改变。在女性中,抑制是在10个月时首次观察到的,到18个月时更为明显。仅限于围孕期的母亲营养不良对后代的肾上腺功能具有长期的,性别依赖性的影响。

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