harmacokinetics and Tolerability of Intravenous Cefotetan Disodium for Injection in Healthy Chinese Volunteers:A Randomized, Open-Label, Single- and Multiple-Dose Study

摘要

Background: Cefotetan disodium for injection is a semisynthetic cephamycin antibiotic that exerts its bactericidal effects by inhibition of cell-wall synthesis. Despite being widely used in the treatment of various infections, little information is available on the pharmacokinetic properties of cefotetan disodium in Chinese subjects.Objectives: This study evaluated the pharmacokinetics of single and multiple intravenous doses of a generic formulation of cefotetan disodium in healthy Chinese volunteers. The effect of sex on the pharmacokinetics of cefotetan disodium was evaluated as a secondary objective.