VEGF-Trap decreases CD4+ T cells, Th17 cytokines improving psoriasis-like skin inflammation in KC-Tie2 mice

摘要

The reddened appearance of lesional psoriasis skin reflects increases in angiogenesis and although this increase is unlikely to be the principle cause of psoriasis it may provide new therapeutic targets. VEGF is a potent mediator of angiogenesis [1], elevated VEGF is found in lesional skin and sera of psoriasis patients and correlates with disease severity and several VEGF genetic polymorphisms have been identified associated with early onset psoriasis.