Biocompatible PLGA-oil hybrid nanoparticles for high loading and controlled delivery of resveratrol

摘要

The art of hybridization has recently emerged as promising strategy to alleviate the limitations associated with PLGA nanoparticles (NPs). The present study reports the development of a hybrid nanosystem by integrating the mechanical advantages of PLGA and high drug encapsulation property of oil into a single system. This hybrid system exhibited core-shell architecture where the oil formed core while PLGA created the outer shell. Several critical factors affecting the formulation of polymer-oil nanohybrids (PONHs) were optimized. The narrow sized (144 nm) PONHs showed remarkable loading capacity (29.2% w/w) and, also showed an improvement in control release capability, antioxidant activity and stability as compared to standard PLGA NPs. Core-shell nature of the PONHs was found a key factor responsible for the improved efficacy. The developed formulations exhibited excellent biocompatibility with normal monkey kidney (Vero) cell lines. The promising results support that PONHs would be a next generation drug delivery system and their strong clinical impact in near future is anticipated. (C) 2015 Elsevier B.V. All rights reserved.