Mesenchymal stem cell proliferation and mineralization but not osteogenic differentiation are strongly affected by extracellular pH

摘要

Osteomyelitis is a serious complication in oral and maxillofacial surgery affecting bone healing. Bone remodeling is not only controlled by cellular components but also by ionic and molecular composition of the extracellular fluids in which calcium phosphate salts are precipitated in a pH dependent manner.