Evaluation of N-(phenylmethyl)-4-(5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo(4,5-c)p yridin-4-yl)benzamide inhibitors of Mycobacterium tuberculosis growth.

Wall MD; Oshin M; Chung GA; Parkhouse T; Gore A; Herreros E; Cox B; Duncan K; Evans B; Everett M; Mendoza A

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Evaluation of N-(phenylmethyl)-4-(5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo(4,5-c)p yridin-4-yl)benzamide inhibitors of Mycobacterium tuberculosis growth.

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Evaluation of N-(phenylmethyl)-4-(5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo(4,5-c)p yridin-4-yl)benzamide inhibitors of Mycobacterium tuberculosis growth.

机译：结核分枝杆菌生长的N-（苯甲基）-4-（5-（苯甲基）-4,5,6,7-四氢-1H-咪唑并（4,5-c）对吡啶-4-基）苯甲酰胺抑制剂的评估。

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The biological evaluation of imidazopiperidines as FAS II inhibitors of Mycobacterium tuberculosis growth has been carried out with a view to assessment of potential as lead compounds for the development of a new TB drug. A summary of the hit evaluation and current challenges is described herein.

机译：已经进行了咪唑并哌啶作为结核分枝杆菌生长的FAS II抑制剂的生物学评估，目的是评估作为开发新型结核病药物的先导化合物的潜力。此处介绍了命中评估和当前挑战的摘要。

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《Bioorganic and Medicinal Chemistry Letters》 |2007年第10期|共5页
作者
Wall MD; Oshin M; Chung GA; Parkhouse T; Gore A; Herreros E; Cox B; Duncan K; Evans B; Everett M; Mendoza A;
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正文语种 eng
中图分类药学;生物化学;
关键词
inhibitors; growth aspects; Mycobacterium tuberculosis; Pulmonary evaluation; 分支杆菌; 结核;

机译：inhibitors;growth aspects;Mycobacterium tuberculosis;Pulmonary evaluation;分支杆菌;结核;

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1. Evaluation of N-(phenylmethyl)-4-(5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo(4,5-c)p yridin-4-yl)benzamide inhibitors of Mycobacterium tuberculosis growth. [J] . Wall MD, Oshin M, Chung GA, Bioorganic and Medicinal Chemistry Letters . 2007,第10期

机译：结核分枝杆菌生长的N-（苯甲基）-4-（5-（苯甲基）-4,5,6,7-四氢-1H-咪唑并（4,5-c）对吡啶-4-基）苯甲酰胺抑制剂的评估。
2. Chiral Auxiliary-Bearing Isocyanides as Synthons: Synthesis of Strongly Fluorescent (+)-5-(3,4-Dimethoxyphenyl)-4-[[N- [(4S)-2-oxo-4-(phenylmethyl)-2-oxazolidinyl]]carbonyl]oxazole and Its Enantiomer [J] . Jian S. Tang, John G. Verkade The Journal of Organic Chemistry . 1996,第25期

机译：手性含辅助异氰酸酯的合成子：强荧光（+）-5-（3,4-二甲氧基苯基）-4-[[N-[（4S）-2-氧代-4-（苯基甲基）-2-恶唑烷酰基）的合成]]羰基]恶唑及其对映异构体
3. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2-pyridylmethoxy) benzamide (AZD7254) [J] . Bioorganic and medicinal chemistry . 2020,第2期

机译：杂芳基胺平滑抑制剂：发现N- [2,4-二甲基-5-（1-甲基-5-（1-甲基咪唑-4-基）苯基] -4-（2-吡啶基甲氧基）苯甲酰胺（AZD8542）和N- [5-（1H-咪唑 -2-y1）-2,4-二甲基 - 苯基] -4-（2-吡啶基甲氧基）苯甲酰胺（AZD7254）
4. Synthesis and Biological Evaluation of N-(5-(pyridin-2-yl)-134-thiadiazol-2-yl)benzamide Derivatives as Lipoxygenase Inhibitor with Potential Anticancer Activity [O] . Alireza Aliabadi, Ahmad Mohammadi-Farani, Sahar Roodabeh, 2017

机译：具有潜在抗癌活性的脂氧合酶抑制剂N-（5-（吡啶-2-基）-134-噻二唑-2-基）苯甲酰胺衍生物的合成及生物学评价
5. An improved synthesis of (S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid ditrifluoroacetate dihydrate (PD123319) [O] . Darren Cundy, Paul A. Gurr, Andrew M. Knill, 2000

机译：[[4-（二甲基氨基）-3-甲基苯基]甲基] -5-（二苯基）-4,5,6,7-四氢-1H-咪唑并[4,5-C - （s）-1的改进的合成]吡啶-6-羧酸二三氟乙酸盐二水合物（pD123319）

Evaluation of N-(phenylmethyl)-4-(5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo(4,5-c)p yridin-4-yl)benzamide inhibitors of Mycobacterium tuberculosis growth.

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