Metabolic bone disease of prematurity (MBDP) is a common and significant problem that often gives rise to osteopenia, fractures, osteomalacia, and osteoporosis. The purpose of our study is to establish normative data on bone status in premature and full-term infants to help future studies on MBDP. Bone status was prospectively determined as part of a multicenter study among newborns within 96 hours of life. The patients were divided into 2 groups: group 1 included those neonates 25-36 wk gestational age (premature), and group 2 neonates were born at 37-42 wk gestational age (full term). Demographic data were collected. The Omnisense 7000 Bone Sonometer (Sunlight Medical Ltd., Tel-Aviv, Israel) was used to determine the speed of sound (SOS) through the mid tibia, which reflects bone strength. A total of 235 patients were enrolled in this study. Group 1 (i.e., the premature infants) had a statistically lower age-adjusted SOS as compared with group 2 (i.e., the full-term infants) (analysis of variance; p=0.001). There was also a correlation between SOS and birth weight (r=0.3; p<001). This study represents the largest database of normative data for bone status measuring in preterm and term infants.
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机译：早产代谢性骨病（MBDP）是一个常见且重要的问题，通常会引起骨质减少，骨折，软化症和骨质疏松症。我们研究的目的是建立有关早产和足月婴儿骨状态的规范性数据，以帮助将来进行MBDP研究。作为一项多中心研究的一部分，对96岁以下新生儿的骨骼状态进行了前瞻性确定。将患者分为2组：第1组包括25-36 wk胎龄（早产）的新生儿，第2组新生儿在37-42 wk胎龄（足月）出生。收集了人口统计数据。 Omnisense 7000骨超声计（以色列，特拉维夫，Sunlight Medical Ltd.）用于确定穿过胫骨中部的声速（SOS），该速度反映了骨骼的强度。本研究共纳入235名患者。与第2组（即足月婴儿）相比，第1组（即早产婴儿）的经年龄调整的SOS在统计学上较低（方差分析; p = 0.001）。 SOS与出生体重之间也存在相关性（r = 0.3; p <001）。这项研究代表了最大的早产和足月儿骨骼状况测量标准数据数据库。
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