首页> 外文期刊>Journal of computer assisted tomography >Multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in human immunodeficiency virus-negative patients: computed tomography features.
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Multidrug-resistant tuberculosis versus drug-sensitive tuberculosis in human immunodeficiency virus-negative patients: computed tomography features.

机译:人类免疫缺陷病毒阴性患者的多药耐药性结核与药敏性结核:计算机断层扫描特征。

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OBJECTIVES:: To compare the computed tomography (CT) features of patients with multidrug-resistant tuberculosis with those of patients with drug-sensitive tuberculosis in a country not associated with the human immunodeficiency virus (HIV) epidemic. METHODS:: The CT images of 47 patients with multidrug-resistant tuberculosis were compared with those of 47 patients with drug-sensitive tuberculosis as a control group. Each multidrug-resistant tuberculosis patient was age (decade) and gender matched to a drug-sensitive tuberculosis patient. All patients were seronegative to HIV. This study evaluated the presence of centrilobular nodules, consolidation, emphysema, bronchiectasis, lung destruction, calcified granuloma, cavitation, pleural effusion, and lymphadenopathy. A statistical comparison was performed by using the Fisher exact test for univariate analysis and a multiple logistic regression method for multivariate analysis. RESULTS:: In univariate analysis, bronchiectasis, lung destruction, a calcifiedgranuloma, and cavitation were more frequently observed in multidrug-resistant tuberculosis than in drug-sensitive tuberculosis. Multivariate analysis showed that cavity formation was the only significant difference between multidrug-resistant tuberculosis and drug-sensitive tuberculosis. In patients with cavitary tuberculosis, multiple cavities (>3 cavities) were observed only in patients with multidrug-resistant tuberculosis. CONCLUSIONS:: Most patients with multidrug-resistant tuberculosis had cavity formation on CT. Although the presence of a cavity does not mean multidrug resistance, multiple cavities suggest the possibility of multidrug-resistant tuberculosis.
机译:目的:比较在与人类免疫缺陷病毒(HIV)流行无关的国家中,耐多药结核病患者与药物敏感性结核病患者的计算机断层扫描(CT)特征。方法:比较47例耐多药结核病患者的CT图像与47例药物敏感性结核病患者的CT图像。每个耐多药结核病患者的年龄(十年)和性别与对药物敏感的结核病患者匹配。所有患者均对HIV呈血清反应阴性。这项研究评估了小叶中心结节,巩固,肺气肿,支气管扩张,肺部破坏,钙化肉芽肿,空化,胸腔积液和淋巴结肿大的存在。通过使用Fisher精确检验进行单变量分析,并使用多元逻辑回归方法进行多变量分析,进行统计比较。结果:在单因素分析中,多药耐药性结核病比药物敏感型结核病更常观察到支气管扩张,肺部破坏,钙化肉芽肿和气蚀。多因素分析表明,空腔形成是耐多药结核病和药物敏感性结核病之间唯一的显着差异。在空洞性肺结核患者中,仅在具有多重耐药性的结核病患者中观察到多个腔体(> 3个腔体)。结论:大多数耐多药结核病患者在CT上形成腔。尽管腔的存在并不意味着具有多重耐药性,但多个腔提示存在多重耐药结核病的可能性。

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