A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma

Rampling Roy; Peoples Sharon; Mulholland Paul J.; James Allan; Al-Salihi Omar; Twelves Christopher J.; McBain Catherine; Jefferies Sarah; Jackson Alan; Stewart Willie; Lindnerl Juha; Kutscher Sarah; Hilf Norbert; McGuigan Lesley; Peters Jane; Hill Karen; Schoor Oliver; Singh-Jasuja Harpreet; Halford Sarah E.; Ritchie James W. A.

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma

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A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma

机译：一项癌症研究英国首次在新诊断为胶质母细胞瘤的患者中进行IMA950（新型多肽治疗疫苗）的人类I期试验

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Purpose: To perform a two-cohort, phase I safety and immunogenicity study of IMA950 in addition to standard chemoradiotherapy and adjuvant temozolomide in patients with newly diagnosed glioblastoma. IMA950 is a novel glioblastoma-specific therapeutic vaccine containing 11 tumor-associated peptides (TUMAP), identified on human leukocyte antigen (HLA) surface receptors in primary human glioblastoma tissue.

机译：目的：对新诊断的胶质母细胞瘤患者，除标准放化疗和替莫唑胺辅助治疗外，还进行IMA950的两类I期安全性和免疫原性研究。 IMA950是一种新型胶质母细胞瘤特异性治疗疫苗，包含11种肿瘤相关肽（TUMAP），在原发性人胶质母细胞瘤组织中的人白细胞抗原（HLA）表面受体上得到鉴定。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2016年第19期|共10页
作者
Rampling Roy; Peoples Sharon; Mulholland Paul J.; James Allan; Al-Salihi Omar; Twelves Christopher J.; McBain Catherine; Jefferies Sarah; Jackson Alan; Stewart Willie; Lindnerl Juha; Kutscher Sarah; Hilf Norbert; McGuigan Lesley; Peters Jane; Hill Karen; Schoor Oliver; Singh-Jasuja Harpreet; Halford Sarah E.; Ritchie James W. A.;
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正文语种 eng
中图分类肿瘤学;
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1. A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma [J] . Rampling Roy, Peoples Sharon, Mulholland Paul J., Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第19期

机译：一项癌症研究英国首次在新诊断为胶质母细胞瘤的患者中进行IMA950（新型多肽治疗疫苗）的人类I期试验
2. Phase Ⅰ/Ⅱ trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients [J] . Migliorini Denis, Dutoit Valerie, Allard Mathilde, Neuro-Oncology . 2019,第7期

机译：在新诊断的成人恶性星形细胞瘤患者中，多肽IMA950 / Poly-ICLC疫苗的多肽IMA950 / Poly-ICLC疫苗的Ⅰ阶段Ⅰ/Ⅱ试验性和免疫原性
3. A Randomized Double-Blind Placebo-Controlled Phase II Trial of Dendritic Cell Vaccine ICT-107 in Newly Diagnosed Patients with Glioblastoma [J] . Wen Patrick Y., Reardon David A., Armstrong Terri S., Clinical cancer research: an official journal of the American Association for Cancer Research . 2019,第19期

机译：在新诊断的胶质母细胞瘤患者中，树突细胞疫苗ICT-107的随机双盲安慰剂对照期II试验
4. RISK-ADAPTED INTRAVENOUS MELPHALAN WITH ADJUVANT THALIDOMIDE AND DEXAMETHASONE FOR NEWLY DIAGNOSED UNTREATED PATIENTS WITH SYSTEMIC AL AMYLOIDOSIS: INTERIM REPORT OF A PHASE II TRIAL [C] . RL Comenzo, P Zhou, L Reich, International Symposium on Amyloidosis . 2005

机译：风险适应的静脉内莫尔甘蔗用佐剂沙利度胺和地塞米松，用于新诊断的未经治疗的全身淀粉样蛋白症患者：II期试验的中期报告
5. Race/Ethnic Disparities in Treatment Patterns among Newly Diagnosed Primary Prostate Cancer Patients in Florida [D] . Williams, Vonetta L. 2015

机译：佛罗里达州新诊断的原发性前列腺癌患者在治疗方式上的种族/种族差异
6. A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multi-Peptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma [O] . Roy Rampling, Sharon Peoples, Paul J. Mulholland, -1

机译：一项癌症研究英国首次在新诊断的胶质母细胞瘤患者中进行IMA950（新型多肽治疗疫苗）的人类I期试验
7. A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma [O] . Rampling, Roy, Peoples, Sharon, Mulholland, Paul J, 2016

机译：英国癌症研究第一次人类I期Ima950（新型多肽治疗性疫苗）在新诊断的胶质母细胞瘤患者中的试验

A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma

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