PURPOSE: To compare anterior capsule contraction in cataract patients having implantation of 1 of 5 foldable intraocular lens (IOL) models and evaluate lens epithelial cell (LEC) adhesion to each model. SETTING: Department of Ophthalmology, Dokkyo Medical University, Tochigi, Japan. METHODS: This study comprised 115 patients (126 eyes) without systemic or ocular complications who had phacoemulsification with IOL implantation. The eyes were randomly assigned to receive 1 of the following IOLs: acrylic MA60BM (Alcon), SA60AT (Alcon), AR40e (Advanced Medical Optics), or YA-60BBR (Hoya) or a silicone AQ310NV (Canon). Two weeks and 1, 3, and 6 months postoperatively, the anterior capsule opening area was measured using an anterior segment analysis system (EAS-1000, Nidek) and the percentage of anterior capsule contraction was compared for each postoperative period and IOL. Cell adhesion to each IOL type was evaluated using LECs from albino rabbits. RESULTS: The mean age of the patients was 73.6 years +/- 5.6 (SD). Eyes with the AQ310NV and AR40e IOLs had statistically significantly greater anterior capsule contraction. The rabbit study showed statistically significantly less LEC adhesion on these 2 IOL models. CONCLUSIONS: Anterior capsule contraction was significantly greater with the AQ310NV and AR40e IOLs than with the other IOLs. Results indicate that cell adhesion to the IOL is an important factor in preventing anterior capsule contraction.
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机译:目的:比较植入5个可折叠人工晶状体(IOL)模型中的1个的白内障患者的前囊收缩情况,并评估每个模型对晶状体上皮细胞(LEC)的粘附性。地点:日本k木县独协医科大学眼科。方法:本研究包括115例(126眼)无系统或眼部并发症的IOL植入患者行超声乳化术。随机分配眼睛以接受以下IOL之一:丙烯酸MA60BM(Alcon),SA60AT(Alcon),AR40e(Advanced Medical Optics)或YA-60BBR(Hoya)或硅树脂AQ310NV(Canon)。术后两周,1、3和6个月,使用前节分析系统(EAS-1000,Nidek)测量前囊开口面积,并比较每个术后时期和IOL的前囊收缩百分比。使用白化兔的LEC评估细胞对每种IOL类型的粘附力。结果:患者的平均年龄为73.6岁+/- 5.6(SD)。带有AQ310NV和AR40e IOL的眼睛在统计学上具有明显更大的前囊收缩。兔子研究显示,在这2种IOL模型上,LEC粘附力在统计学上显着降低。结论:AQ310NV和AR40e IOL的前囊收缩明显大于其他IOL。结果表明细胞对IOL的粘附是防止前囊收缩的重要因素。
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