Does a sharp edge compress the posterior capsule in vivo? 16863942

摘要

Nagamoto and Fujiwara1 conclude from their in vitro study that inhibition of cell migration at the optic edge of an intraocular lens (IOL) may be regulated by the degree of contact pressure between the optic edge and posterior capsule. A sharp capsule bend does not in itself inhibit cell migration.I have comments and questions for the authors. First, this conclusion is based on an in vitro study, which differs from in vivo conditions. Zonular tension, aqueous humor, and vitreous were not present in this model. Furthermore, the authors' conclusion is based on the assumption that contact pressure will arise at the optic edge clinically in vivo. Contradictory to their conclusion, there are some facts as well as in vivo experimental and clinical findings opposing the thesis that contact pressure arises at the optic edge. Some in vivo findings also indicate that a sharp capsule bend in itself inhibits cell migration.