Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm.

摘要

OBJECTIVE: To estimate population pharmacokinetic parameters of repaglinide in 121 healthy Malaysian volunteers. METHODS: Each subject received 4 mg of oral repaglinide. Six blood samples were taken per individual (0, 30, 60, 120, 180 and 240 min) for repaglinide's serum concentration determination by using high-performance liquid chromatography. The parametric Iterative Two-Stage Bayesian Population Model (it2b) program followed by the Non-Parametric Adaptive Grid (npag) program was used to determine a population pharmacokinetic modelling of repaglinide. RESULTS: Using the npag program, the mean elimination rate constant (k(el)) of repaglinide was 0.58 +/- 0.27 h and the volume of distribution (V(d)) was 23.09 +/- 9.19 L/h. CONCLUSION: In this first report, specifically on the population pharmacokinetic modelling of repaglinide, the data generated should help us to better understand appropriate dosage-regimens for the drug.