Background and objective: Pertussis developed in Kagawa University Medical School and University Hospital in May 2007. To control the outbreak and prevent the infection of hospital inpatients, the Infection Control Team (ICT) carried out the prophylactic administration of erythromycin (EM) to hospital staff (1566 staff) who might be exposed to Bordetella pertussis. Methods: An oral dose of 1000 mg/day EM was given for 10 days. To assess compliance and estimate the frequency of adverse effect, the ICT conducted a questionnaire survey. Results and discussion: Of 942 respondents (response rate: 60.2%), 264 (28.0%) experienced some form of EM adverse effects, of which the most commonly reported involved digestive organ symptoms, e.g. diarrhoea (15.6%), stomachache (7.5%), nausea (3.6%), epigastric distress (2.1%) and abdominal distention (1.8%). More importantly, 246 participants (26.1%) stopped taking the EM before completing 10 days because of perceived adverse effects. Conclusion: These results indicate that EM appears to cause adverse effects more frequently than reported in the package insert in Japan. The prophylactic use of EM for pertussis infection is recognized in the guideline of the Centers for Disease Control and Prevention. However, this study suggests that attention should be paid to EM non-compliance during a pertussis outbreak, which could extend the duration of the outbreak and increase the number of affected patients.
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机译：背景与目的：2007年5月在香川大学医学院和大学医院研制出百日咳。为控制疫情并预防住院病人的感染，感染控制小组（ICT）对医院工作人员进行了红霉素（EM）的预防性管理（1566名员工）可能暴露于百日咳博德特氏菌。方法：口服1000 mg / day EM，持续10天。为了评估合规性并估计不良影响的频率，ICT进行了问卷调查。结果与讨论：在942名受访者中（回应率：60.2％），有264名（28.0％）经历了某种形式的EM不良反应，其中最常报告的涉及消化器官症状，例如消化不良。腹泻（15.6％），胃痛（7.5％），恶心（3.6％），上腹窘迫（2.1％）和腹胀（1.8％）。更重要的是，有246名参与者（26.1％）由于感觉到不良反应而在完成10天之前停止服用EM。结论：这些结果表明，EM引起的不良反应似乎比日本包装说明书中所报道的更为频繁。疾病控制与预防中心的指南中已确认EM预防百日咳感染的用途。但是，这项研究建议在百日咳暴发期间应注意EM不合规，这可能会延长暴发的持续时间并增加患病人数。
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