Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity

Suryadevara Carter M.; Riccione Katherine A.; Samspon John H.

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Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity

机译：免疫治疗已失去病毒：硼替佐米和oHSV增强抗肿瘤NK细胞活性

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Oncolytic viruses, proteasome inhibitors, and natural killer (NK)-cell immunotherapy have all been studied extensively as monotherapies but have never been evaluated in combination. Synergetic treatment of oncolytic virus-infected glioblastomas with a proteasome inhibitor induces necroptotic cell death to enhance NK-cell immunotherapy, prolonging survival against human glioblastoma. (C) 2016 AACR.

机译：溶瘤病毒，蛋白酶体抑制剂和自然杀伤（NK）细胞免疫疗法已作为单一疗法进行了广泛研究，但从未进行过组合评估。用蛋白酶体抑制剂协同治疗溶瘤病毒感染的胶质母细胞瘤可诱导坏死性细胞死亡，从而增强NK细胞免疫疗法，延长抗人胶质母细胞瘤的生存期。（C）2016 AACR。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2016年第21期|共3页
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Suryadevara Carter M.; Riccione Katherine A.; Samspon John H.;
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正文语种 eng
中图分类肿瘤学;
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1. Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity [J] . Suryadevara Carter M., Riccione Katherine A., Samspon John H. Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第21期

机译：免疫治疗已失去病毒：硼替佐米和oHSV增强抗肿瘤NK细胞活性
2. ABT-199, a BH3 mimetic that specifically targets Bcl-2, enhances the antitumor activity of chemotherapy, bortezomib and JQ1 in "double hit" lymphoma cells [J] . Johnson-Farley Nadine, Veliz Jonny, Bhagavathi S., Leukemia and lymphoma . 2015,第7期

机译：ABT-199是一种专门针对Bcl-2的BH3模拟物，可增强“双重打击”淋巴瘤细胞中化疗，硼替佐米和JQ1的抗肿瘤活性。
3. Interactions of the Hdm2/p53 and proteasome pathways may enhance the antitumor activity of bortezomib. [J] . Ooi MG, Hayden PJ, Kotoula Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第23期

机译：Hdm2 / p53和蛋白酶体途径的相互作用可能会增强硼替佐米的抗肿瘤活性。
4. ANTITUMOR ACTIVITY OF PHOTODYNAMIC THERAPY, ADOPTIVE IMMUNOTHERAPY AND CHEMOTHERAPY IN EXPERIMENTAL TUMOR [C] . Gianfranco Canti, Angela Calastretti, Rinaldo Cubeddu, Society of Photo-Optical Instrumentation Engineers Conference on Laser Interaction with Tissue and Cells . 2004

机译：光动力治疗，养护免疫疗法和实验性肿瘤化疗的抗肿瘤活性
5. Oncolytic adenoviruses in combination treatments for cancer: Examining the roles of cyclophosphamide and radiation in enhancing antitumor efficacy and viral replication and biodistribution in the Syrian hamster. [D] . Young, Brittany A. 2013

机译：溶瘤腺病毒在癌症联合治疗中的作用：研究环磷酰胺和放射线在增强叙利亚仓鼠的抗肿瘤功效以及病毒复制和生物分布方面的作用。
6. Immunotherapy gone viral: Bortezomib and oHSV enhance antitumor NK cell activity [O] . Carter M. Suryadevara, Katherine Riccione, John H. Sampson -1

机译：免疫疗法病毒化：硼替佐米和oHSV增强抗肿瘤NK细胞活性
7. DDIS-28. GENE THERAPY WITH oHSV-1 CD/5-FC EXHIBIT ENHANCED ANTITUMOR EFFICACY IN GLIOMA CELL LINE AND INTRACRANIAL MURINE GLIOMA MODEL [O] . Fusheng Liu, Sheng Fang, Bo Zhang, 2018

机译：DDIS-28。具有OHSV-1 CD / 5-FC的基因治疗表现出胶质瘤细胞系和颅内鼠胶质瘤模型的增强抗肿瘤效果

Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity

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