Does oxidized LDL contribute to atherosclerotic plaque formation and microvascular complications in patients with type 1 diabetes?

摘要

Objective: The aim of the study was to investigate whether changes in the level of oxidized LDL (oxLDL) over 2-years contribute to the development of subclinical macroangiopathy and/or microvascular complications in patients with DM1. Design and methods: Basic clinical and biochemical parameters and oxLDL level were measured in 70 patients at baseline and after 2. years of the study. In addition, an ultrasonographic study was performed to assess the carotid intima media thickness (IMT). Results: Patients did not differ according to basic clinical and biochemical parameters at the beginning and after 2. years of the study. IMT increased (p = 0.000001) whereas oxLDL level decreased (p = 0.00001) in DM1 patients during 2. years. Multivariate regression analysis showed that oxLDL independently influences IMT in DM1 patients (β = 0.454, R2 = 0.35). Further, positive correlations between oxLDL value and LDL-C concentration (r = 0.585, p < 0.05, n = 70) and between oxLDL level and apo-B concentration have been established (r = 0.610, p < 0.05, n = 70). Moreover, patients with chronic microvascular complications showed a higher value of IMT in comparison with patients without them (p = 0.003). Conclusion: Our results provide the evidence that oxLDL accelerates atherosclerotic plaque formation and may contribute to the development of microvascular complications in DM1.