Synthesis of a Solid-Phase Amino Imidazotriazine Library via Palladium Catalyzed Direct Arylation

摘要

Heteroarenes, including imidazoles and triazines, are important structural units frequently found in natural products, pharmaceuticals, and agrochemicals. The biological importance and structural variation of heterocyclic derivatives provide a significant synthetic challenge, particularly when concerned with efficiently synthesizing large numbers of discrete analogues. Modern combinatorial chemistry plays a key role in the search for lead structures displaying biological activity and represents a powerful methodology for the synthesis of compound libraries for biological evaluation.