Efficient synthesis of novel oxime analogues of the hormone 1 alpha, 25-dihydroxyvitamin D-3

摘要

Calcitriol analogues which contained an oxime in the side chain were synthesised in five steps from an intermediate 22-nor Ketone. The key intermediate enones were synthesised by the Wittig-Horner olefination and Wittig olefination respectively. Reduction, oximation, photoisomerisation and deprotection gave the target compounds with the oxime at C-24.