An efficient, one-pot synthesis of spiro[dihydropyridine-oxindole] compounds under catalyst-free conditions

摘要

An efficient one-pot synthesis of the biologically important spiro[dihydropyridine-oxindole] scaffolds from isatins, 2-naphthylamine and 1,3-dicarbonyl compounds in poly (ethylene glycol) 400/H_2O under catalyst-free conditions is described. The reaction is free of catalysts and toxic solvents, operates under neutral conditions and allows for ease of product isolation, making it more environmentally friendly and suitable for large-scale operations.