Green synthesis of 5-aryl-(1 H,3H,5H,10H)-pyrimido[4,5-b]quinoline-2,4- diones catalysed by 1,4-diazabicyclo[2.2.2]octane in water

摘要

A green and efficient synthesis of 13 of the title compounds, three of which are novel, has been achieved via a one-pot, three- component reaction of anilines, aldehydes and barbituric acids, catalysed by 1,4-diaza-bicyclo[2.2.2]octane (DABCO) in water at reflux. Using microwave heating, reaction times were shortened from 12 h to under a minute and yields were generally higher.