Isoindolone synthesis via palladium-catalysed intramolecular amination of benzylic C-H bonds

摘要

A new method for the construction of isoindolones is presented in this paper. Four 7-methyl-2-(8-quinolinyl) -2, 3-dihydro-1H-isoindol-1-ones were synthesised from 2,6-dimethyl -N-(8-quinolinyl)benzamides via intramolecular direct amination of benzylic C-H bonds. This approach provides a convenient method affording structurally new isoindolones for medicinal chemistry research.