A green and efficient synthesis of 1-chloromethyl -2, 3, 4, 5-tetramethoxy-6-methylbenzene

摘要

The title compound, a key intermediate for preparing coenzyme Q analogues, was prepared in excellent yield by a reaction sequence starting from the commercially available 3,4,5-trimethoxybenzadehyde via Wolff-Kishner reduction, selective bromination, methoxylation and Blanc chloromethylation reaction.