Diversity Oriented Synthesis of Benzimidazole and Benzoxa/(thia)zole Libraries through Polymer-Supported Hypervalent Iodine Reagent

摘要

The development of new therapeutic agents, as well as the identification of molecular probes for the study of the chemical/biological interfaces, is one of the major goals in biomedical research. In this context, the availability of large libraries of small organic molecules, covering as much chemical space as possible, is seen as the only means which guarantees potential modulation of the many biological targets that are ultimately being unveiled by genomics. Therefore, advances in drug discovery depend heavily on the availability of synthetic transformations that allow the rapid assembly of complex molecular frameworks providing maximum diversity.