Prospect of Metal-Catalyzed C—C Forming Cross-Coupling Reactions in Modern Solid-Phase Organic Synthesis

摘要

Solid-phase organic synthesis (SPOS) has evolved in the past few years to become a widely used tool for the preparation of a large number of structurally diverse compounds for combinatorial libraries. The generation of molecular diversity by solid-phase methodologies was originally focused on the synthesis of the peptide and oligonucleotide libraries. However, after the pioneering work by Ellman in the solid-phase synthesis of benzodiazepines, the scope of polymer-supported chemistry was expanded beyond the preparation of those biopolymers to reach the synthetically more complicated, drug-like, small organic molecules.