Soluble Polymer-Supported Synthesis of Thioxotetrapyrimidinone by Focused Microwave Irradiation

摘要

With more and more therapeutic targets emerging from chemical genomics research, combinatorial chemistry provides fast access to large quantities of structurally diverse libraries to fuel the chemical genetics. Limitations in efficiency of classical chemical synthesis resulting from tedious workup and purification can be overcome by solid-phase synthesis due to advantages such as easy and fast purification. However, solid-phase chemistry suffers from various problems, such as the heterogeneous nature of the reaction condition, a reduced rate of reactions, solvation of the bound species, and mass transport of reagents. We have been interested in employing liquid-phase combinatorial technology as a means of efficient constructing multifunctional libraries. This strategy enables standard solution-based chemistry to be utilized, and purification of the is just like that of solid-phase reactions. Furthermore, monitoring the progress of reactions on the support is significantly simplified by using conventional analytical methods.