Divergent Solution-Phase Synthesis of Diarylpyrimidine Libraries as Selective A3 Adenosine Receptor Antagonists

摘要

The implementation of flexible and conceptually simple, as well as time- and cost-effective, synthetic methodologies that bring about rapid access to diverse compound libraries is one of the main goals in combinatorial chemistry.This objective is critical in drug discovery because the availability of large libraries of small organic molecules, covering as much chemical space as possible, is seen as the only means to guarantee potential modulation of the many biological targets that are ultimately being unveiled by genomics.