Essential fatty acid-deprived tube-fed adults synthesize arachidonic and docosahexaenoic acids: a pilot analysis of the fatty acid status of people with profound developmental disabilities.

摘要

OBJECTIVE: Determine whether there are essential fatty acid abnormalities in arachidonic (AA) and docosahexaenoic acid (DHA)-deprived tube-fed individuals. DESIGN AND METHODS: Plasma fatty acid concentrations were measured in eight tube-fed adults with profound developmental disabilities. RESULTS: Mean plasma AA, DPAn-6, stearic, oleic, Mead, palmitoleic, and vaccenic acid concentrations were elevated but DHA was normal. Numerous fatty acid ratios were also elevated. CONCLUSIONS: In this context, significant synthesis of both AA and DHA was apparent. However, abnormal fatty acid profiles were common.