A facile solvent-free synthesis of high specific activity potassium [C-14]formate and ethyl [C-14]formate under microwave irradiation

摘要

Potassium [C-14]cyanide was first hydrolysed to potassium [C-14]formate with dilute alkali under microwave (1300 W) irradiation for 8 min in a sealed glass ampoule. Potassium [C-14]formate was then esterified with triethyl orthophosphate under microwave irradiation for 20 min to furnish ethyl [C-14]formate having high specific radioactivity (50 mCi/mmol) in an yield of 98%.