Synthesis of dinorcholane and 5 beta-cholane derivatives

摘要

The convenient synthesis of seven dinorcholane and 5beta-cholane derivatives, 3beta-acetoxy-23,24-dinorchol-5-en-22-oyl methoxy anhydride (2), 3beta-acetoxy-23,24-dinorchol-5-en-22-oyl chloride (3), 3beta-acetoxy-23,24-dinorchol-5-en-22-ol (4), 3alpha-acetoxy-5p-cholan-24-oic acid (6), 3alpha-acetoxy-5beta-cholan-24-oic acid ethyl ester (7), 3-oxo-5beta-cholan-24-oic acid (8) and 3-oxo-5beta-cholan-24-oic acid ethyl ester (9) have been described. Full spectroscopic data for these compounds are presented.