Rosacea: advances in understanding pathogenesis and treatment

摘要

Rosacea is a common, chronic inflammatory skin disease that primarily affects the face. There is a wide range of clinical features in rosacea including persistent erythema, facial flushing, telangiectasia, inflammatory papules and phymas. The National Rosacea Society Expert Committee has identified four major subtypes of rosacea based on groups of these symptoms: erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea and ocular rosacea. The pathophysiology of rosacea has not been completely elucidated; however, recent research into this disorder has identified several potential etiologic agents and processes that contribute to the disease. The synthesis of this research allows us to begin to understand how our current therapies work and provides us potential targets for future therapies. This article will review our current theories of rosacea pathogenesis, outline treatment options and discuss avenues for future research.