Means limiting the expression of the gene encoding histamine receptor H2 and/or an antagonist of histamine receptor H2 for the treatment of e.g. rosacea, erythematotelangiectatic rosacea and papulopustular rosacea (subtype II)

摘要

Means limiting the expression of the gene encoding histamine receptor H2 (HRH-2) and/or an antagonist of the HRH-2 for the treatment of rosacea, is claimed. Independent claims are included for: (1) a pharmaceutical composition comprising, in a medium, at least one means limiting the expression of the gene encoding the HRH-2 and/or the antagonist of the HRH-2; (2) an in vitro method for diagnosis of rosacea in a subject likely to be achieved, comprising: (a) evaluation of expression levels or activity rate of HRH-2, in a biological sample previously collected from a patient with rosacea, (b) comparison of the level of expression or the rate of HRH-2 activity, measured in the step (a) with respect to the same rate measured in a healthy subject, (c) evaluation of expression levels or HRH-2 activity rate in a biological sample previously taken from the subject suffering from rosacea, and (d) comparing the level of expression or rate of HRH receptor-2 activity, measured in the step (c) with respect to the same rate measured in the step (a) and in a healthy subject; (3) an in vitro method for monitoring the development of rosacea in a patient with rosacea, comprising (i) evaluation of the expression rate or rate of HRH-2 activity in the biological sample previously taken from the subject with rosacea, at a given time t1; (ii) at a given time t2, after time t1 of the first step, evaluation of the level of expression or activity rate of HRH-2 in a second biological sample previously taken from the patient with rosacea; (iii) comparing the level of expression or activity rates of HRH-2, measured in the first step with respect to the same rate measured at the step (ii); and (4) a kit for diagnosis or monitoring the development of rosacea, comprising at least one means of measuring the expression or activity of HRH-2 in the skin cells of a subject. ACTIVITY : Dermatological. MECHANISM OF ACTION : Histamine receptor H2 modulator.