Higher circulating GlycA, a pro-inflammatory glycoprotein biomarker, relates to Lipoprotein-associated phospholipase A(2) mass in nondiabetic subjects but not in diabetic or metabolic syndrome subjects

摘要

BACKGROUND: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a cardiovascular risk marker, which is in part complexed to low-density lipoproteins, where it exerts pro-inflammatory properties. GlycA is a pro-inflammatory proton nuclear magnetic resonance spectroscopy biomarker whose signal originates from a subset of N-acetylglucosamine residues on the most abundant glycosylated acute-phase proteins.