Energetics of the Na(+) pump in the heart.

摘要

Movement of ions across the cell membrane is driven by the free energy released from ATP hydrolysis. Here we will briefly review the chemistry of Na(+), K(+)-ATPase reaction; we will also review some recent results defining the relationship between the energetic driving force and Na(+) efflux by the Na(+) pump in the normal myocardium and then discuss this relationship for pathophysiologic states in the heart.