Levels of 17 beta-Hydroxysteroid Dehydrogenase Type 10 in Cerebrospinal Fluid of People with Mild Cognitive Impairment and Various Types of Dementias

摘要

Background: Overexpression of the mitochondrial enzyme 17 beta-hydroxysteroid dehydrogenase type 10 (17 beta-HSD10, which is also known as the intracellular amyloid-beta peptide (A beta) binding protein) is observed in cortical or hippocampal regions of patients with Alzheimer's disease (AD). It appears that 17 beta-HSD10 may play a role in the pathogenesis of AD.