Comparative pharmacokinetics of Enrofloxacin and Marbofloxacin after a single intramuscular administration in camel.

摘要

The comparative serum pharmacokinetics of Enrofloxacin (E) and Marbofloxacin (M) were determined following an intramuscular dose of 5 mg/kg and 2.5 mg/kg body weight, respectively in camels. The data obtained was best fitted to 2-compartment open model. The maximum peak concentration of Enrofloxacin was 2.6 micro g/ml and Marbofloxacin was 1.7 micro g/ml obtained after 1.93 and 1.80 hours, respectively. The t_1/2 was 4.03 for Enrofloxacin and 7.1 hours for Marbofloxacin. The t_1/2, MRT and AUC were significantly greater for marbofloxacin than enrofloxacin.