Comparison of wound-bursting strengths and surface characteristics of FDA-approved tissue adhesives for fkin closure

摘要

We compared the wound-bursting strength (WBS),mode of adhesive failure adn surface characteristics of two FDA-approved tissue adhesives for skin closure i an incisional rat model using a randomized,controlled,blind animal experiment.Standardized 2-cm full-thickness incisions were made in duplicate on both sides of 15 rats and closed with indermil,or high viscosity dermabond (HVD)following manufactures' instruction.WBS was measured 5 min later witha validated commercial instrument.Wound sectins were also observed under light and scanning electron microscopies.Indermil was significantly weaker than HVD (mean difference,143 mmHg;95%CI,42-229 mmHg,P=0.002).The mode of failure for indermil was primarily cohesive in the adhesive and the primary failure mode for the HVD was interfacial (X~2,P<0.01).Microscopic observations demonstrated that application of HVD resulted in a thick,uniform and smooth surface while indermil resulted in a thin,irregular,carcked surface.we conclde that hvd is stronger,thicker and more uniform than indermil.