Safety and Pharmacokinetics of Oral Cannabidiol When Administered Concomitantly With Intravenous Fentanyl in Humans

Manini Alex F.; Yiannoulos Georgia; Bergamaschi Mateus M.; Hernandez Stephanie; Olmedo Ruben; Barnes Allan J.; Winkel Gary; Sinha Rajita; Jutras-Aswad Didier; Huestis Marilyn A.; Hurd Yasmin L.

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Safety and Pharmacokinetics of Oral Cannabidiol When Administered Concomitantly With Intravenous Fentanyl in Humans

机译：口服芬太尼与人同时使用时口服卡那比二醇的安全性和药代动力学

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Objectives: Cannabidiol (CBD) is hypothesized as a potential treatment for opioid addiction, with safety studies an important first step for medication development. We determined CBD safety and pharmacokinetics when administered concomitantly with a high-potency opioid in healthy subjects.

机译：目的：假设将卡纳比多醇（CBD）作为阿片类药物成瘾的潜在疗法，而安全性研究是药物开发的重要第一步。在健康受试者中与高效阿片类药物同时给药时，我们确定了CBD安全性和药代动力学。

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《Journal of addiction medicine》 |2015年第3期|共7页
作者
Manini Alex F.; Yiannoulos Georgia; Bergamaschi Mateus M.; Hernandez Stephanie; Olmedo Ruben; Barnes Allan J.; Winkel Gary; Sinha Rajita; Jutras-Aswad Didier; Huestis Marilyn A.; Hurd Yasmin L.;
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正文语种 eng
中图分类药学;
关键词
cannabidiol; cannabis; opioid dependence; pharmacokinetics;

机译：大麻二酚;大麻;阿片类药物依赖性;药代动力学;

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1. Safety and Pharmacokinetics of Oral Cannabidiol When Administered Concomitantly With Intravenous Fentanyl in Humans [J] . Manini Alex F., Yiannoulos Georgia, Bergamaschi Mateus M., Journal of addiction medicine . 2015,第3期

机译：口服芬太尼与人同时使用时口服卡那比二醇的安全性和药代动力学
2. Pharmacokinetics of fentanyl administered transdermally and intravenously in sheep [J] . Ahern Benjamin J., Soma Lawrence R., Rudy Jeffrey A., American Journal of Veterinary Research . 2010,第10期

机译：绵羊芬太尼经皮和静脉内给药的药代动力学
3. Single-dose pharmacokinetics of orally administered metronidazole and intravenously administered imipenem in healthy horses and computer-based simulation of pleural fluid concentrations with multiple dosing [J] . Kuroda Taisuke, Nagata Shun-ichi, Tamura Norihisa, American Journal of Veterinary Research . 2020,第10期

机译：口服甲硝唑的单剂量药代动力学，静脉内施用于健康马匹和基于计算机的胸腔流体浓度的计算机模拟，具有多剂量
4. Pharmacokinetics of intravenous and oral firocoxib in preweaned calves and evaluation of perioperative analgesia following cautery dehorning [C] . Matthew L. Stock, Ronette Gehring, Suzanne T. Millman, Annual Conference of the American^Association^of^Bovine^Practitioners. . 2014

机译：静脉内和口服呋喃唑的药代动力学在核发脱毛后静脉级颅尔和围手术期镇痛评估
5. Pharmacokinetic Evaluation of a Novel Compound, SN79, a Putative Sigma-2 Receptor Antagonist, by Intravenous and Oral Administration in Rats. [D] . Vinnakota, Harsha. 2011

机译：通过大鼠静脉内和口服给药对新型化合物SN79（一种公认的Sigma-2受体拮抗剂）进行药代动力学评估。
6. Safety and pharmacokinetics of oral cannabidiol when administered concomitantly with intravenous fentanyl in humans [O] . Alex F. Manini, Georgia Yiannoulos, Mateus M. Bergamaschi, -1

机译：静脉注射芬太尼与人同时口服口服大麻素的安全性和药代动力学
7. Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans [O] . J Zempleni, J R Galloway, D B McCormick 1996

机译：口服和静脉内给药的药代动力学健康人体中的核苷酸
8. Effect of Repeated Oral Doses of Ethiprole on the Biliary Excretion and Pharmacokinetics of Intravenously Administered 1251-Thyroxine (T4) in Male Rats [R] . 2008

机译：口服重复口服乙醚对雄性大鼠静脉注射1251-甲状腺素（T4）胆汁排泄和药代动力学的影响

Safety and Pharmacokinetics of Oral Cannabidiol When Administered Concomitantly With Intravenous Fentanyl in Humans

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