Immunity to Measles, Mumps, and Rubella in US Children With Perinatal HIV Infection or Perinatal HIV Exposure Without Infection

摘要

Unlike human immunodeficiency virus (HIV)-exposed but uninfected children, many perinatally HIV-infected children lack serologic evidence of immunity to measles, mumps, and rubella despite past immunization and current antiretroviral therapy (ART). Effective ART before immunization is a strong predictor of current seroimmunity.Methods.aEuro integral PHIV and HEU children were enrolled in the Pediatric HIV/AIDS Cohort Study (PHACS) at ages 7-15 years from 2007 to 2009. At annual visits, demographic, laboratory, immunization, and clinical data were abstracted and serologic specimens collected. Most recent serologic specimen was used to determine measles seroprotection by plaque reduction neutralization assay and rubella seroprotection and mumps seropositivity by enzyme immunoassay. Sustained combination antiretroviral therapy (cART) was defined as taking cART for at least 3 months.