Novel Technique for Fabricating Double-Layered Tubular Constructs Consisting of Two Vascular Cell Types in Collagen Gels Used as Templates for Three-Dimensional Tissues

摘要

Double-layered tubular constructs consisting of two vascular cell types in collagen gels were fabricated using a previously developed technique [Takei et ah,Biotechnol.Bioeng.,95,1-7(2006)].Histological examination suggested that shear stress(4.0 dyn/cm~2)on the luminal surface of the constructs induced morphological changes in their walls.