Development and Characterization of a Novel Amorphous Calcium Phosphate/Multi (Amino Acid) Copolymer Composite for Bone Repair

摘要

Objective: To develop and characterize a novel bone graft substitute, calcium Phosphate/multi (amino Acid) copolymer composite (ACP/MAC) for treatment of large bone defects. Methods. A novel bioactive composite for bone regeneration was fabricated by incorporating of amorphous calcium phosphate (ACP) into multi (amino acid) copolymer (MAC). The composition, interface and bioactivity of the composite were characterized. Results: The ACP crystals were in spherical shape with a size of 30 to 80 nm in diameter. In the ACP/MAC composite, ACP was evenly distributed in MAC matrix without chemical bonds formation between the matrix. After being soaked into simulated body fluid (SBF) for 4 days, the ACP/MAC composite developed apatite deposition on the surface of ACP/MAC. Conclusions: The novel ACP/MAC composite is a promising bone graft substitute with good bioactivity.