Linear Type Azo-containing Polyurethanes for Colon-specific Drug Delivery

摘要

New biodegradable polyurethanes containing azo-linked polymeric prodrugs of 5-aminosalicylic acid (5-ASA) in the main chain were prepared by reacting 1,6-Hexamethylenediisocyanate (HDD with 3,3'-azobis(6-hydroxy benzoic acid) (ABHB) and 5-[4-(hydroxyl phenyl) azo] salicylic acid (HPAS) as azo derivatives of 5-ASA.The polymers were characterized by FTIR and ~1H-NMR spectroscopy.The hydrolysis of polyurethane containing azo-deriva-tives of 5-ASA was carried out in cellophane membrane dialysis bags containing aqueous buffer solution (pH=8.5 and pH=l) at 37degC.Detection of the hydrolysis product by UV spectroscopy showed that ABHB and HPAS were released by the hydrolysis of the urethane bond in the polymer chain.