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COLON-SPECIFIC DRUG DELIVERY USING INTERPOLYMER COMPLEXATIONS
COLON-SPECIFIC DRUG DELIVERY USING INTERPOLYMER COMPLEXATIONS
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机译:使用高分子间复合物递送结肠特定药物
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摘要
The technical field of the invention relates to pharmaceutical compositions for delivering drugs in the colon using an interpolymer complexation of a cationic polymeric glucosamine or its derivatives and an anionic, cross-linked, polyacrylic acid or its derivatives. The colon-specific drug delivery system includes (a) a core that includes a pharmaceutically active agent, a solid particulate inter-polymer complex of a cationic polymeric glucosamine or its derivatives and an anionic, cross-linked, polyacrylic acid or its derivatives; and (b) a pH-dependent coating surrounding at least a portion of the core, the pH-dependent coating being insoluble in gastric fluid and intestinal fluid below pH 6.0 but soluble in the colonic intestinal environment.
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